Lynne M. Dieckman, MS, PhD
Lynne M. Dieckman, MS, PhD

Lynne M. Dieckman, MS, PhD

Assistant Professor
College of Arts and Sciences

Academic Appointments

Department

  • Chemistry

Position

  • Assistant Professor

Publications and Presentations

Articles

  • Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway
     , Journal of Biological Chemistry, 293 (29), 11271-11282, 2018
  • Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring
     , PLoS One, 13(3), e0193333, 2018
  • Aspirin, McGraw Hill, 055900, 2017
  • Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis, PLoS One, 11(6), e0157023, 2016
  • Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective, Nucleic Acids Research, 30, 85-108, 2014
  • Distinct Structural Alterations in PCNA Block DNA Mismatch Repair, Biochemistry, 52 (33), 5611-5619, 2013
  • PCNA Trimer Instability Inhibits Translesion Synthesis by DNA Polymerase Eta and by DNA Polymerase Delta, DNA Repair, 12 (5), 367-376, 2013
  • PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA, Springer Science+Business Media LLC, 62, 281-299, 2012
  • Pre-steady State Kinetic Studies of the Fidelity of Nucleotide Incorporation by Yeast DNA Polymerase Delta, Biochemistry, 49 (34), 7344-7350, 2010

Research and Scholarship

Research and Scholarship Interests


  • Research in the Dieckman lab focuses on the mechanisms by which errors in DNA replication and repair and chromatin organization lead to genome instability and disease.  Specifically, our main goal is to characterize the interactions of key factors that are essential for the interplay between genomic and epigenetic stability.  Two of these factors include the proteins PCNA (the processivity factor that stimulates DNA polymerases during DNA replication and repair) and CAF-1 (the main histone chaperone that is necessary for packaging DNA into nucleosomes following replication and repair).  The interaction between PCNA and CAF-1 is crucial for proper DNA synthesis, assembly of nucleosomes, and preservation of epigenetic marks.  Students will learn biochemical techniques used in modern biomedical research in order to determine the mechanistic basis of the network of interactions between CAF-1, PCNA, DNA, and other factors during replication-dependent nucleosome assembly and to work towards an understanding of proper DNA maintenance.

Grant Funding Received

  • Dr. George F. Haddix President’s Faculty Research Fund, Creighton University
  • National Institutes of Health INBRE Program, DRPP
  • National Science Foundation Nebraska EPSCoR FIRST Award
  • Center for Undergraduate Research and Scholarship Faculty Research Fund.