Annemarie Shibata, BA, PhD
Annemarie Shibata, BA, PhD

Annemarie Shibata, BA, PhD

Associate Professor
College of Arts and Sciences

Academic Appointments

Department

  • Biology

Position

  • Associate Professor

Secondary Appointment

  • School of Medicine

Education

  • Creighton University,B.S.,1988-1992
  • Colorado State University,Ph.D.,1992-1997

Publications and Presentations

Articles

  • Date, A. A., Shibata, A., Bruck, P., Destache, C. J. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates, Biomedical Chromatography : BMC, 29, 709-715, 2015
  • Date, Abhijit A., Shibata, Annemarie, McMullen, Emily, La Bruzzo, Krista, Bruck, Patrick, Belshan, Michael, Zhou, You, Destache, Christopher J. Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles for Prevention of HIV-1 Infection, Journal of Biomedical Nanotechnology, 11, 416-427, 2015
  • Shibata A, McMullen E, Pham A, Belshan M, Sanford B, Zhou Y, Goede M, Date AA, Destache CJ. Polymeric nanoparticles containing combination antiretroviral drugs for HIV type 1 treatment., AIDS Research in Human Retroviruses, 29 (5), 746-54, 2013
  • Date, Abhijit A., Shibata, Annemarie, Goede, Michael, Sanford, Bridget, Bruzzo, Krista L., Belshan, Michel, Destache, Christopher J. Development and evaluation of a thermosensitive vaginal gel containing raltegravir? +? efavirenz loaded nanoparticles for HIV prophylaxis, Antiviral Research, 96, 430-436, 2012
  • Destache, C. J., Belgum, T., Goede, M., Shibata, A., Belshan, M. A. Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice, Journal of Antimicrobial Chemotherapy, 65, 2183-2187, 2010
  • Destache, C. J., Belgum, T., Christensen, K., Shibata, A., Sharma, A., Dash, A. Combination antiretroviral drugs in PLGA nanoparticle for HIV-1, BMC infectious diseases, 9, 198, 2009

Presentations

  • Erik Arneson, Taylor Mighell, Megan Bosch, Garrett Soukup, Shibata A, Dicer Knockout mice suggest a cirtical role of microRNA in cerebellar cell proliferation, organization and migration. International Society for Neuroscience Meeting.San Diego CA Nov 2014., 2014
  • Johnson A.K., Mathy N.W., Tappata M., Shibata A. Cortical neuronal damage stimulates a microRNA and epigenetic-associated transition in activated microglia that enhances neuronal differentiation and survival. International Society for Neuroscience Meeting.San Diego CA Nov 2014., 2014
  • Erik Arneson, Taylor Mighell, Megan Bosch, Garrett Soukup, Shibata A, Dicer Knockout mice suggest a cirtical role of microRNA in cerebellar cell proliferation, organization and migration. Nebreaska EpScore Meeting September 2014., 2014
  • Johnson A.K., Mathy N.W., Tappata M., Shibata A. Cortical neuronal damage stimulates a microRNA and epigenetic-associated transition in activated microglia that enhances neuronal differentiation and survival. Nebreaska EpScore Meeting September 2014., 2014
  • Mighell T, Bosch M, Arneson E, Shibata A. Granule cell specific Dicer knockout mice indicate essential role of microRNA in cerebellar development. International Society for Neuroscience Meeting. Nov 2013, 2013
  • Mighell T, Bosch M, Arneson E, Pierce M, Steenson S, Soukup G, and Shibata A. Granule cell specific Dicer knockout mice indicate essential role of microRNA in cerebellar development. 7th Annual MidBrains Conference. Carleton College, Northfield MN, October 5, 2013., 2013
  • Mighell T, Bosch M, Arneson E, Pierce M, Steenson S, Soukup G, and Shibata A. Granule cell specific Dicer knockout mice indicate essential role of microRNA in cerebellar development. 9th Annual Nebraska Neuroscience Symposium. Omaha, NE, October 3. 2013., 2013
  • Chen J, Shibata A. In Response to Damage Activated Microglia Enhance Neuronal Differentiation and Survival American Association of Anatomists 125th Annual Meeting, April 21, 2013 No. 4995, 2013
  • Mighell T, Bosch M, Arneson E, Steenson S, Pierce P, Soukup G, Shibata A. Essential Role of Dicer and microRNA in Cerebellar Development West Coast Biological Sciences Undergraduate Research Conference. Point Loma Nazarene University, San Diego, CA April 20th, 2013., 2013
  • Abhijit A. Date, Shibata A , Emily McMullen, Krista La Bruzzo, Christopher Destache (2012) Thermosensitive vaginal gel containing efavirenz loaded cellulose acetate phthalate nanoparticles for HIV prophylaxis Creighton University, Omaha, NE 68178, USA CROI, 2012
  • Jing Chen, Irsa Shoiab, and Annemarie Shibata, (2012) NEUROTROPHIC EFFECTS OF MICROGLIA VIA ACTIVATION OF AKT SIGNALING AND EPIGENETIC MODIFICATION Department of Biology, Creighton University, Omaha, NE 68178-0103 122nd Annual Meeting of the Nebraska Academy of Sciences, Lincoln,NE., 2012
  • Bosch M, Hake A, Pierce M, Soukup G, Shibata A (2012) Dicer, don’t leave home without it. 122nd Annual Meeting of the Nebraska Academy of Sciences, Lincoln,NE., 2012
  • Krista LaBruzzo , Date A, Destache CJ, Shibata A (2012) Determination of the effication of nanoparticle antiretroviral drug delivery systems using cellular model systems. Ferlic Scholars Presentation Creighton University, Omaha NE, 2012
  • Jing Chen, Irsa Shoiab, and Annemarie Shibata, (2012) NEUROTROPHIC EFFECTS OF MICROGLIA VIA ACTIVATION OF AKT SIGNALING AND EPIGENETIC MODIFICATION Department of Biology, Creighton University, Omaha, NE 68178-0103 Biology Department Student Research Colloquium. Creighton University, Omaha,NE., 2012
  • Hake A, Bosch M,, Pierce M, Soukup G, Shibata A (2012) Biology Department Student Research Colloquium. Creighton University, Omaha,NE., 2012
  • *Bosch M, Hake A, Pierce M, Soukup G, Shibata A (2011) Analysis of cerebellar development and function in conditional Dicer knockout mice. International Society for Neuroscience Meeting. Nov 2011 Abstract No.10519, 2011
  • Bosch M, Hake A, Pierce M, Soukup G, Shibata A (2011) Analysis of cerebellar development and function in conditional Dicer knockout mice. International Society for Neuroscience Meeting. Nov 2011 Abstract No.10519, 2011
  • Bosch M, Hake A, Pierce M, Soukup G, Shibata A (2011) Dicer, don’t leave home without it. 121st Central Regional IDeA Conference, Omaha, NE May 24, 2011., 2011
  • Destache CJ, Goede M, McMullen E, Pham A, Shibata A (2011) Sub-cellular fractionation and confocal microscopy for nanoparticle antiretroviral drugs in HIV-infected cell lines Keystone symposia, Whistler, British Columbia Canada Mar 20-26., 2011
  • Destache CJ, Goede M, McMullen E, Pham A, Shibata A (2011) Sub-cellular fractionation and confocal microscopy for nanoparticle antiretroviral drugs for HIV-infected cell lines (2011) 18th Conference on Retrovirus and Opportunistic Infections Boston MA, Feb 27-Mar 2., 2011
  • Bosch M, Hake A, Pierce M, Soukup G, Shibata A (2011) Dicer, don’t leave home without it. 121st Annual Meeting of the Nebraska Academy of Sciences, Lincoln,NE., 2011
  • Shoiab I, Shibata A (2011) RT-PCR analysis of microglial neurotrophic properties. Annual Meeting of the Nebraska Academy of Sciences, Lincoln,NE., 2011
  • McMullen E, Pham, A, Goede M, Destache CJ (2011) HIV-1 protein concentration and gene regulation altered upon treatment with antiretroviral nanoparticles. 121st Annual Meeting of the Nebraska Academy of Sciences, Lincoln,NE., 2011
  • McMullen E, Pham A, Goede M, Destache CJ, Shibata A (2011) Viability, protein, and immunofluorescent analysis of HIV-1 infected cells treated with antiretroviral therapy nanoparticles. Biology Department Student Research Colloquium. Creighton University, Omaha,NE., 2011
  • Shoiab I, Shibata A (2011) RT-PCR analysis of microglial neurotrophic properties. Biology Department Student Research Colloquium. Creighton University, Omaha,NE., 2011
  • Hake A, Bosch M, Pierce M, Soukup G, Shibata A (2011) Correlation of Atoh1-Cre dicer null mutant mice behavior with cerebllar development.Biology Department Student Research Colloquium. Creighton University, Omaha,NE., 2011

Research and Scholarship

Grant Funding Received

  • NIH-NIAID, R15 AREA Grant. Title: Integrase Inhibitor Combination Nanomicrobicide for Prevention of HIV Infection $436,500, Funding period: 2/1/2015-1/31/2017 Role: Principal investigator Key personnel: Dr. Chris Destache, School of Pharmacy Sciences, Creighton University *funds 8 undergraduate students
  • Clinical and Translational Research Grant, Development of thermosensitive gel containing tenofovir nanoparticles for HIV prophylaxis $59,991 Role: Co-PI, PI: Abhijit Date *funds an undergraduate student in my lab
  • NIH/UNMC/INBRE New Pilot Project Grant, Analysis of the role of miRNA in cerebellum development. $63,000 Role: Principal investigator and research educator for undergraduate INBRE scholars
  • NIH/UMNC/INBRE, Intracellular and epigenetic mechanism underlying neurotrophic properties of activated microglia. $31,000 approximate annual stipend, $189,130 total award Role: Principal investigator and research educator for undergraduate INBRE scholars
  • Investigator Award (Shibata as PI) Summer Faculty Research Fellowship $5000 Investigation of epigenetic regulation underlying microglial neuroprotection Role: PI
  • Undergraduate Research Student Training Award (Shibata as PI) $5000 Evaluating the role of non-coding RNA in cerebellar granule cell neural networks. Role: PI
  • Investigator Award (Shibata as PI) George Haddix Faculty Research Fund $15,000 Elvitegravir Nanoparticles for Prevention of HIV Infection Role: PI
  • George F Haddix President’s Faculty Research Fund, Combined nanofabrications for antiretroviral pre-exposure prophylaxis, $15,000 Role: Co-PI with Chris Destache, Pharm. D, Professor of Pharmacy Practice
  • President Faculty Research Fund, Interdisciplinary team application, Determination of the Efficacy of Nanoparticle Driven Antiretroviral Drug Delivery Systems using Cellular Model Systems. Requested Amount $10,000 Role: Co-PI with Chris Destache, Pharm. D, Professor of Pharmacy Practice
  • Summer Faculty Research Fellowship Award, Analysis of Nanoparticle Driven Antiretroviral Drug Delivery Systems using Cellular Model Systems $5000.00 Role: Principal investigator

Awards and Honors

  • Teacher of the Month Award, Gamma Phi Beta Phi, Creighton University, 2011
  • Summer Faculty Research Fellowship, Creighton University, 2011