Martin R. Hulce, PhD
Martin R. Hulce, PhD

Martin R. Hulce, PhD

Professor
College of Arts and Sciences

Academic Appointments

Department

  • Chemistry

Position

  • Professor

Secondary Appointment

  • School of Medicine

Biography

A more complete listing of scholarly activities can be found on my Curriculum Vitae.

Education

  • Butler University, B.S.,1974-78
  • The Johns Hopkins University, M.A.,1979-80
  • The Johns Hopkins University, Ph.D.,1980-83

Publications and Presentations

Articles

  • Gubbels, M. A.; Hulce, M.; Kum, J. M.; Urick, A. K.; Villa, E. M. Stereoselective Synthesis of Exocyclic Allenes by Double Hydride Reduction of 3-Alkynyl-2-cycloalkenones”, Tetrahedron, 72, 6052-6063, 2016
  • Munt, D. J.; Grana, A.; Hulce, M.; Fusaro, R. M.; Dash, A. K. “Effect on simultaneous administration of dihydroxyacetone on the diffusion of lawsone through models for stratum corneum and epidermis for use as a UV protectant”, AAPS PharmSciTech, 16(6), 1425-1433, 2015
  • Smith, D. D.; Gallagher, A. T.; Crowley, V.; Gergens, W. M.; Abel, P.W.; Hulce, M. “An Efficient Synthesis of 4(5)-Benzyl-L-Histidines Employing Catalytic Transfer Hydrogenation at Elevated Temperatures”, Synthesis, 46(4), 515-521, 2014
  • Carney, John M., Hammer, Reagan J., Hulce, Martin, Lomas, Chad M., Miyashiro, Dayna "Microphotochemistry Using 5-mm Light-Emitting Diodes: Energy-Efficient Photooxidations", Synthesis, 44(16), 2560-2566, 2012
  • Carney, John M., Hammer, Reagan J., Hulce, Martin, Lomas, Chad M., Miyashiro, Dayna "High-efficiency microphotooxidation using milliwatt LED sources", Tetrahedron Letters, 52(2), 352-355, 2011
  • Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. "N-Terminal bis(2-Chloroethyl)amino & Fluorosulfonyl Analogues of Calcitonin Gene-Related Peptide(8-37): Irreversible Antagonists at Calcitonin Gene-Related Peptide Receptors", Chemical Biology and Drug Design, 70, 216-226, 2007
  • Taylor, C.K.; Smith, D.D.; Hulce, M.; Abel, P.W. “Pharmacological Characterization of Novel High Affinity CGRP Receptor Antagonists that are Selective for Human CGRP Receptors", Journal of Pharmacology and Experimental Therapeutics, 319, 749-757, 2006
  • Mattson, B.; Hulce, M; Cheng, W.; Greimann, J.; Hoette, T; Menzel, P. “Propanol to Propane. An Advanced Laboratory Experiment Using Two Gas-phase Heterogeneous Catalysts", Journal of Chemical Education, 83, 421-424, 2006
  • Taylor, C.K.; Abel, P.W.; Hulce, M.; Smith, D.D. “Solvent Effects on Coupling Yields During Rapid Solid Phase Synthesis of CGRP(8-37) Employing in situ Neutralization", Journal of Peptide Research, 65, 84-89, 2005
  • Reidelberger, R.D.; Hernandez, J.; Fritzsch, B.; Hulce, M. “Abdominal Vagal Mediation of the Satiety Effects of CCK in Rats", American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 286, R1005-R1012, 2004
  • Reidelberger, R.D.; Castellanos, D.; Hulce, M. “Effects of Peripheral CCK Receptor Blockade on Food Intake in Rats”, American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 285, R429-R437, 2003
  • Smith, D.D.; Saha, S.; Fang, G.; Schaffert, C.; Waugh, D.J.J.; Zeng, W.; Toth, G.; Hulce, M.; Abel, P.W. “Modifications to the N-terminus but not the C-terminus of Calcitonin gene-Related Peptide(8-37) Produces Antagonists with Increased Affinity for CGRP Receptors", Journal of Medicinal Chemistry, 46, 2427-2435, 2003
  • Reidelberger, R.D.; Heimann, D.; Kelsey, L.; Hulce, M. “Effects of Peripheral CCK Receptor Blockade on Feeding Responses to Duodenal Nutrient Infusions in Rats", American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 284, R389-R398, 2003
  • Reidelberger, R.D.; Kelsey, L.; Heimann, D.; Hulce, M. “Effects of Peripheral CCK Blockade on Gastric Emptying in Rats", American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 284, R66-R75, 2003
  • Trætteberg, M.; Khaikin, L.S.; O.E. Grikina, O.E.; Liebman, J.F.; Hulce, M. “Structure, Spectra, & Intramolecular Motions of 1,4-Bis(trimethylsilyl)-1,3-butadiyne: an Electron Diffraction Study Using the Results of Spectral Analysis Based on Scaled Quantum-Chemical Force Field for Calculating Vibrational Effects", Journal of Molecular Structure, 559, 295-313, 2001
  • Hulce, M.; Marks, D.W. “Organic Solvent-Free Phase-Transfer Oxidation of Alcohols Using Hydrogen Peroxide", Journal of Chemical Education, 78, 66-68, 2001
  • Malone, J.A.; Reidelberger, R.D.; Hulce, M. “Synthesis of a Radiolabelled type A Cholecystokinin Receptor Antagonist, (R)-N-pentyl-N-(4,5-di[3H]pentyl) Nα-(3-quinolinoyl)glutamic acid amide", Journal of Labelled Compounds & Radiopharmaceuticals, 43, 77-90, 2000

Publications

  • Smith, D. D.; Gallagher, A.; Gergens, W.; Crowley, V.; Abel, P.W.; Hulce, M. “Revisiting and Optimizing the Synthesis of 4-Benzyl-L-Histidine and Analogues”, Peptides: Building Bridges, Lebl, M., ed; Prompt Scientific Publishing: San Diego, 34-35, 2011
  • Smith, D.D.; Mao, M.; Young, H.; Hulce, M. "Synthesis of 4-Arylmethyl-L-hisitidine analogues for Structure-Activity Studies of Position 10 of CGRP", Advances in Experimental Medicine and Biology, 611, 313-132, 2009
  • Smith, D.D.; Hulce, M.; Waugh, D.J.J.; Abel, P.W. “Structural Characterization of Dibenzylated-CGRP(8-37), a Byproduct from the N-α-Benzylation of CGRP(8-37)", Peptides: The Wave of the Future, 2002, 205-251, 2002

Presentations

  • Steele, E. L.; Hulce, M.; Smith, D. D.  “Synthesis of Boc-His(4-Bn)(Bom)-OH and Fmoc-His(4-Bn)(Bom)-OH for the Solid Phase Peptide Synthesis of Nα-Bn-[BnHis]-CGRP(8-37).”  Midwest Regional Meeting of the American Chemical Society, Manhattan, KS, 2016, 380., 2016
  • Lynch, D. G.; Hulce, M.  “Synthesis of dihydroxacetone derivatives as potential sun-protection agents.”  Midwest Regional Meeting of the American Chemical Society, Manhattan, KS, 2016, 193.

     , 2016
  • Mason, N. J.; Hulce, M.; Smith, D. D.  “Synthesis of truncated calcitonin gene-related peptide analogues by Fmoc coupling with modified histidines.”  Midwest Regional Meeting of the American Chemical Society, Manhattan, KS, 2016, 191., 2016
  • Hulce, M. “A ‘Poor Man’s Atomic Bomb’: One Hundred and One Years of Chemical Warfare.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2016, 92., 2016
  • Gubbels, M. A.; Villa, E. M.; Hulce, M. “Stereoselective synthesis of Exocyclic Cumulatrienes by 1,2-, 1,6- Double Hydride Reduction.” Creighton University St. Albert’s Day Student Research Forum, Omaha, NE, 2016, 17., 2016
  • Meerovich, I.; Dash, A. K.; Smith, D. D.; Hulce, M. “Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting.” American Association of Pharmaceutical Scientists Annual Meeting, November 2-6, 2014, San Diego, CA, R6010., 2015
  • Smith, D. D.; Livens, P. A.; Hulce, M. “Optimizing the Preparation of 4(5)-Benzyl-L-Histidine Methyl Ester, as Intermediate in the Preparation of Protected Derrivative of 4(5)-Benzyl-L-Histidine for Peptide Synthesis.” Midwest Regional Meeting of the American Chemical Society, St. Joseph, MO, 2015, 241., 2015
  • Gubbels, M. A.; Huang, R. W.; Villa, E. M.; Hulce, M. “Determining the Stereochemical Outcome of 3-alkynyl- and 3-alkenyl-2-cycloalkenone Double Hydride Reductions.” Midwest Regional Meeting of the American Chemical Society, St. Joseph, MO, 2015, 358., 2015
  • Gubbels, M.; Huang, R.; Villa, E.; Hulce, M. “Unambiguous Determination of the Stereochemical Outcome of 3-Alkynyl- and 3-Alkenyl-2-cycloalkenone Double Hydride Reductions.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2015, 66., 2015
  • Cokingtin, B. M.; Cokingtin, K. P.; Ishihara, R. T.; Hulce, M.; Smith, D. D. Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidines Suitable for Solid-phase Peptide Synthesis.” Midwest Regional Meeting of the American Chemical Society, Columbia, MO, 2014, 597., 2014
  • Mitchell, B.; Smith, D. D.; Hulce, M. “Preparation of Nα,Nπ-bis(t-Butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2014, 112., 2014
  • Griggs, C.; Hulce, M.; Smith, D. D. “Studies Toward the Synthesis of Fmoc-N-methyl-β-(tert-butyldimethylsilyloxy)-L-valine Using the Schöllkopf Chiral Auxillary.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2014, 114., 2014
  • Mekada, H.; Hulce, M.; Smith D. D. “Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of a 4(5)-Benzyl-L-histidinyl Tripeptide Using Fmoc-based Solid-phase Peptide Synthesis.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2014, 75., 2014
  • Smith, D. D.; Griggs, C.; Mitchell, B.; Mekada, H.; Hulce, M. “Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidine.” 248th American Chemical Society National Meeting, San Francisco, CA, 2014, ORGN 263., 2014
  • Kang, Y. C.; Turco, L. M.; Hulce, M. “Endoperoxidation Versus Ene Reaction of Cyclone Analogues: An Investigation Using LED Microphotochemistry.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 316., 2013
  • Mekada, H.; Hulce, M.; Smith D. D. “Investigation of Racemization During SPPS of the Tripeptide 4(5)-Bn-L-His-L-Ala- -L-Gly.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 78., 2013
  • Griggs, C.; Hulce, M.; Smith, D. D. “Synthesis of N-Methyl-L-β-hydroxyvaline Using the Schöllkopf Chiral Auxillary.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 294., 2013
  • Kang, Y. C.; Turco, L. M.; Hulce, M. “Endoperoxidation Versus Ene Reaction ofCyclone Analogues: An Investigation Using LED Microphotochemistry.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 316., 2013
  • Griggs, C.; Hulce, M.; Smith, D. D. “Synthesis of N-Methyl-L-B-hydroxyvaline Using the Schollkopf Chiral Auxillary.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 294., 2013
  • Mekada, H.; Hulce, M.; Smith D. D. “Investigation of Racemization During SPPS of the Tripeptide 4(5)- Bn-L-His-L-Ala- -L-Gly.” Midwest Regional Meeting of the American Chemical Society, Springfield, MO, 2013, 78., 2013
  • Kum, J. M.; Urick, A. K.; Hulce, M. “Stereoselective synthesis of exocyclic allenes by double hydride reduction of 3-trimethylsilylethynyl-2-cycloalkenones.” Midwest Regional Meeting of the American Chemical Society, Omaha, NE, 2012, 89., 2012
  • Christensen, J. A.; Smith, D.D.; Hulce, M. “Towards the Synthesis of Pargamicin A: Preparation of Beta- Hydroxyvaline.” Midwest Regional Meeting ofthe American Chemical Society, Omaha, NE, 2012, 276., 2012
  • Munt, D.J.; Dash, A.K.; Hulce, M.; Fussaro, R. “Permeability of DHA and the Effect of DHA on the Permeability of Lawsone Across a Pig Skin.” American Association of Pharmaceutical Scientists Annual Meeting, Chicago, IL, M1052., 2012
  • Kum, J. M.; Urick, A. K.; Hulce, M. “Exocyclic Allenes by Lithium Aluminum Hydride Reduction of 3-Trimethylsilylethynyl-2-cycloalkenones.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2012, 85., 2012
  • Smith, D. D.; Gallagher, A.; Gergens, W.; Crowley, V.; Abel, P.W.; Hulce, M. “An Improved synthesis of 4(5)-Benzyl-L-Histidine.” Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2012, 84., 2012
  • Hulce, M. “Flashlight Photochemistry.” Earl H. and Marian A. Beling Lectureship, Illinois Wesleyan University, Bloomington, IL, 2012., 2012
  • Kum, J. M.; Urick, A. K.; Hulce, M. “Rapid Access to Exocyclic Allenes by Double Hydride Reduction of3-Trimethylsilylethynyl-2-cycloalkenones.” Joint Midwest/Great Lakes Regional Meeting of the American Chemical Society, St. Louis, MO, 2011, 175., 2011
  • Smith, D. D.; Gallagher, A.; Gergens, W.; Crowley, V.; Abel, P.W.; Hulce, M. “Studies Towards to Synthesis Synthesis of Protected Derivatrives of 4(5)-Benzylhistidine suitable for Peptide Synthesis.” Joint Midwest / Great Lakes Regional Meeting ofthe American Chemical Society, St. Louis, MO, 2011, 247., 2011
  • Munt, D. J.; Fusaro, R. M.; Hulce, M.; Dash, A. “Permeability of DHA and its Effect on the Transport of Lawsone Across a Snake Skin Model for Stratum Corneum.” American Association of Pharmaceutical Scientists Annual Meeting, Washington, DC, T3133, 2011
  • Smith, D. D.; Gallagher, A.; Gergens, W.; Crowley, V.; Abel, P.W.; Hulce, M. “Revisiting and Optimizing the Synthesis of 4-Benzyl-L-Histidine and Analogues.” 22nd American Peptide Symposium, San Diego, CA, 2011., 2011
  • Carney, J. M.; Hammer, R. J.; Lomas, C.M.; Miyashiro, D.; Hulce, M. “High-efficiency Microphotooxidation Using Milliwatt LED Sources.” 45th Midwest Regional Meeting of the American Chemical Society, Witchita, KS, 2010, 353., 2010
  • Gallagher, A. T.; Hulce, M.; Smith, D. D. “Optimizing the Synthesis of 4-Benzyl-L-Histidine,” 45th Midwest Regional Meeting ofthe American Chemical Society, Witchita, KS, 2010, 243., 2010
  • Smith , D. D.; Gallagher, A. T.; Gergens, W.; Abel, P.W.; Hulce, M. “Analogues of4-Benzyl-L- Histidine for Structure Activity Studies of a CGRP Antagonist.” 45th Midwest Regional Meeting of the American Chemical Society, Witchita, KS, 2010, 180, 2010
  • Gergens, W.; Smith, D. D.; Hulce, M. “Synthesis of4(5)-Fluorobenzyl L-histidine Analogues.” 45th Midwest Regional Meeting ofthe American Chemical Society, Witchita, KS, 2010, 29., 2010
  • Hammer, R. J.; Hulce, M. “Sequential Photooxidation–decarbonylation: Stereoselective Synthesis of (Z)-Stilbenes.” 45th Midwest Regional Meeting ofthe American Chemical Society, Witchita, KS, 2010, 8., 2010
  • Carney, J.M.; Lomas, C.M.; Miyashiro, D.; Hulce, M. “High-efficiency Microphotooxidation Using Milliwatt LED Sources,“ Proceedings of the Nebraska Academy of Sciences, Lincoln, NE, 2010, 80., 2010

Awards and Honors

  • Berkley Heights: "Who's Who in America", Marquis Who's Who, 2015
  • Creighton University Research Award, 2013
  • Cambridge: "Top 100 Professionals 2013", International Biographical Centre, 2013
  • Famington Hills: "American Men & Women of Science", Gale Cengage, 2012