Mark V. Reedy, PhD
Mark V. Reedy, PhD

Mark V. Reedy, PhD

Associate Professor
Chair, Biology Department, College of Arts and Sciences
College of Arts and Sciences

Academic Appointments

Department

  • Biology

Position

  • Associate Professor

Teaching Activity

  • BIO 202 General Biology: Cellular and Molecular
  • BIO 362 Cell Structure and Function
  • BIO 467 Developmental Biology

Biography

I am interested in the factors that guide cell and tissue movements during embryonic development since his undergraduate days at the University of Kansas.  Much of my work has focused on a population of cells called neural crest cells and the mechanisms they use to follow the correct path as they migrate extensively throughout the early embryo.  More recently, I have been using avian embryos as a model system for studying the mechanisms behind nicotine-induced birth defects.  I  joined the Creighton faculty in 2001 and became department chair in 2009. Prior to that, I was a postdoctoral research fellow at The M.D. Anderson Cancer Center, and earned my Ph.D. from the University of California at Davis.  

Publications and Presentations

Books

  • R.J. Grebenok, T. Leustek, H. Nickla, G.J. Podgorski, M. Reedy and D.L. Welker. Student Handbook for Genes VIII: Questions, Problems, and Solutions., Prentice Hall, 2004

Articles

  • Patterson, R. A.; Cavanaugh, A. M.; Cantemir, V.; Brauer, P. R.; Reedy, M. V. MT2-MMP Expression During Early Avian Morphogenesis. Anatomical record., Anatomical Record, 296, 64-70, 2013
  • Heidenreich, D. J., Reedy, M. V., Brauer, P. R. Homocysteine enhances cardiac neural crest cell attachment in vitro by increasing intracellular calcim levels, Development Dynamics, 237, 2117-2128, 2008
  • D. B. Gould, M.V. Reedy, L.A. Wilson, R.A. Smith, R.L Johnson and S. W. M. John. Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma., Molecular and Cellular Biology, 26, 8427-8436, 2006
  • D.M. Parichy, M.V. Reedy, and C.A. Erickson. Regulation of Melanoblast Migration and Differentiation. Chapter 5 in The Pigmentary System: Physiology and Pathophysiology, 2nd ed. J.J. Nordlund et al., eds., Oxford University Press, 108-139, 2006
  • Cantemir, V., Cai, D. H., Reedy, M. V., Brauer, P. R. Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration and its role in proMMP-2 activation, Developmental Dynamics, 231, 709-719, 2004
  • B. J. Tierney, T. Ho, M.V. Reedy, and P. R. Brauer. Homocysteine inhibits neural crest cell formation and morphogenesis in vivo., Development Dynamics, 229, 63-73, 2004
  • Cole, DG and Reedy, MV. Algal morphogenesis: How Volvox turns itself inside-out., Current Biology, 13, R770-R772, 2003
  • Reedy, MV; Johnson, RL; Erickson, CA. The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development. Gene Expression Patterns., Gene Expression Patterns, 3, 53-58, 2003
  • B.S. Kim, O.V. Savinova, M.V.Reedy, Y. Lun, L. Gan, S.I Tomarev, S.W.M. John, and R.L. Johnson. Targeted disruption of myocilin (MYOC) suggests that glaucoma-causing mutations of myocilin in humans are gain of function mutations., Molecular and Cellular Biology, 21, 7707-7713, 2001
  • R. Kos, M.V. Reedy, R. Johnson, and C.A. Erickson. The winged helix transcription factor cFoxD3 is important for establishing the neural crest lineage and repressing melanogenesis., Development, 128, 1467-1479, 2001
  • M.V. Reedy, C. D. Faraco, and C. A. Erickson. Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens., Developmental Dynamics, 213, 476-485, 1998
  • M.V. Reedy, C. D. Faraco, and C. A. Erickson. The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube., Developmental Biology, 200, 234-246, 1998
  • C.A. Erickson and M.V. Reedy. Neural crest development: the interplay between morphogenesis and cell differentiation., Current Topics in Developmental Biology, 40, 178-209, 1998

Research and Scholarship

Research and Scholarship Interests

  • cell and tissue differentiation and morphogenesis during vertebrate development

Current Research Projects

  • mechanisms of nicotine-induced teratogenic effects in early embryos

Grant Funding Received

  • National Institutes of Health. The role of TIMP-2 in neural crest pathfinding. 05/09-04/2014. J. Turpen, P.I. and M. V. Reedy, sub-contract P.I. Total subcontract award: $155,435.
  • Creighton University Medical Center. Congenital neurocristopathies and nicotine. P.R. Brauer, P.I., M.V. Reedy, co-P.I., and D.D. Smith, co-P.I. 08/09-07/11. Total award: $79,088.

Awards and Honors

  • Robert F. Kennedy Memorial Award for Teaching Achievement, Creighton University Students Union, 2018
  • Distinguished Service Faculty Award, Creighton University, 2015
  • Service to Youth Award, Bellevue Public Schools, Bellevue NE, 2013
  • College Award for Outstanding Major Advising, College of Arts and Sciences, 2009