Mark V. Reedy, Ph.D.
Mark V. Reedy, Ph.D.

Mark V. Reedy, Ph.D.

Associate Professor
Chair, Biology Department, College of Arts and Sciences
College of Arts and Sciences

Academic Appointments

Department

  • Biology

Position

  • Associate Professor

Teaching Activity

  • Cell Biology
  • Developmental Biology
  • General Biology

Biography

Dr. Reedy has been studying the factors that guide cell and tissue movements during embryonic development since his undergraduate days at the University of Kansas.  Much of his work has focused on a population of cells called neural crest cells and the mechanisms they use to follow the correct path as they migrate extensively throughout the early embryo.  More recently, he has been using avian embryos as a model system for studying the mechanisms behind nicotine-induced birth defects.  He teaches courses in the areas of cell and developmental biology, and has collaborations with colleagues at the Creighton University School of Medicine. Dr. Reedy joined the Creighton faculty in 2001 and became department chair in 2009. Prior to that, he completed a postdoctoral research fellowship at The M.D. Anderson Cancer Center, and earned his Ph.D. from the University of California at Davis.  

Education

  • B.S., Cell Biology, University of Kansas 1992
  • B.A., Political Science, University of Kansas 1992
  • Ph.D., Cell and Developmental Biology, University of California at Davis 1998
  • Postdoctoral Fellowship, M.D. Anderson Cancer Research Center 2001

Publications and Presentations

Books

  • R.J. Grebenok, T. Leustek, H. Nickla, G.J. Podgorski, M. Reedy and D.L. Welker. Student Handbook for Genes VIII: Questions, Problems, and Solutions., Prentice Hall, 2004

Articles

  • Patterson, R. A.; Cavanaugh, A. M.; Cantemir, V.; Brauer, P. R.; Reedy, M. V. MT2-MMP Expression During Early Avian Morphogenesis. Anatomical record., Anatomical Record, 296, 64-70, 2013
  • Heidenreich, D. J., Reedy, M. V., Brauer, P. R. Homocysteine enhances cardiac neural crest cell attachment in vitro by increasing intracellular calcim levels, Development Dynamics, 237, 2117-2128, 2008
  • D. B. Gould, M.V. Reedy, L.A. Wilson, R.A. Smith, R.L Johnson and S. W. M. John. Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma., Molecular and Cellular Biology, 26, 8427-8436, 2006
  • D.M. Parichy, M.V. Reedy, and C.A. Erickson. Regulation of Melanoblast Migration and Differentiation. Chapter 5 in The Pigmentary System: Physiology and Pathophysiology, 2nd ed. J.J. Nordlund et al., eds., Oxford University Press, 108-139, 2006
  • Cantemir, V., Cai, D. H., Reedy, M. V., Brauer, P. R. Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration and its role in proMMP-2 activation, Developmental Dynamics, 231, 709-719, 2004
  • B. J. Tierney, T. Ho, M.V. Reedy, and P. R. Brauer. Homocysteine inhibits neural crest cell formation and morphogenesis in vivo., Development Dynamics, 229, 63-73, 2004
  • Cole, DG and Reedy, MV. Algal morphogenesis: How Volvox turns itself inside-out., Current Biology, 13, R770-R772, 2003
  • Reedy, MV; Johnson, RL; Erickson, CA. The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development. Gene Expression Patterns., Gene Expression Patterns, 3, 53-58, 2003
  • B.S. Kim, O.V. Savinova, M.V.Reedy, Y. Lun, L. Gan, S.I Tomarev, S.W.M. John, and R.L. Johnson. Targeted disruption of myocilin (MYOC) suggests that glaucoma-causing mutations of myocilin in humans are gain of function mutations., Molecular and Cellular Biology, 21, 7707-7713, 2001
  • R. Kos, M.V. Reedy, R. Johnson, and C.A. Erickson. The winged helix transcription factor cFoxD3 is important for establishing the neural crest lineage and repressing melanogenesis., Development, 128, 1467-1479, 2001
  • M.V. Reedy, C. D. Faraco, and C. A. Erickson. Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens., Developmental Dynamics, 213, 476-485, 1998
  • M.V. Reedy, C. D. Faraco, and C. A. Erickson. The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube., Developmental Biology, 200, 234-246, 1998
  • C.A. Erickson and M.V. Reedy. Neural crest development: the interplay between morphogenesis and cell differentiation., Current Topics in Developomental Biology, 40, 178-209, 1998

Research and Scholarship

Research and Scholarship Interests

  • cell and tissue differentiation and morphogenesis during vertebrate development

Current Research Projects

  • mechanisms of nicotine-induced teratogenic effects in early embryos

Grant Funding Received

  • National Institutes of Health. The role of TIMP-2 in neural crest pathfinding. 05/09-04/2014. J. Turpen, P.I. and M. V. Reedy, sub-contract P.I. Total subcontract award: $155,435.
  • Creighton University Medical Center. Congenital neurocristopathies and nicotine. P.R. Brauer, P.I., M.V. Reedy, co-P.I., and D.D. Smith, co-P.I. 08/09-07/11. Total award: $79,088.

Awards and Honors

  • Distinguished Service Faculty Award, Creighton University, 2015
  • Service to Youth Award, Bellevue Public Schools, Bellevue NE, 2013
  • College Award for Outstanding Major Advising, College of Arts and Sciences, 2009