Gwendalyn King, PhD
Gwendalyn King, PhD

Gwendalyn King, PhD

Assistant Professor
College of Arts and Sciences


  • Neuroscience

Academic Appointments


  • Biology


  • Assistant Professor

Secondary Appointment

  • Graduate School

Teaching Activity

  • BIO 362 Cell Structure and Function
  • BIO 462 Neurobiology
  • BIO 463 Neurobiology laboratory
  • NES 510 Neurophysiology lab
  • NES/BIO 464 Neurobiology of Disease

Publications and Presentations


  • A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells., Journal of Molecular Cell Biology, 12, 4-16, 2020
  • FGF23 expression is stimulated in transgenic -Klotho longevity mouse model, JCI: Insight, 4, 2019
  • Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis, Am J Physiol Lung Cell Mol Physiol, 217, L141-L154, 2019
  • Klotho deficiency affects the spine morphology and network synchronization of neurons., Molecular and Cellular Neuroscience, 98, 1-11, 2019
  • FGF-23 Deficiency Impairs Hippocampal-Dependent Cognitive Function, Eneuro, 6, 2019
  • Klotho, the Key to Healthy Brain Aging?, Brain Plasticity, 3, 183-194, 2018
  • Fibroblast growth factor 23 and Klotho contribute to airway inflammation., European Respiratory Journal, 52, 2018
  • Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene., J Am Soc Nephrol, 29, 69-80, 2018
  • Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss., Neurobiology of Aging, 59, 41-54, 2017
  • Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia., Sci Rep, 7, 2017
  • Klotho regulates CA1 hippocampal synaptic plasticity., Neuroscience, 347, 123-133, 2017
  • Adult-born neurons modify excitatory synaptic transmission to existing neurons, Elife, 6, 2017
  • Differential Regulatory Role of Soluble Klothos on Cardiac Fibrogenesis in Hypertension., Am J Hypertension, 29, 1140-47, 2016
  • Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport., PLoS One, 2016
  • Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages., FEBS Lett., 590, 53-67, 2016
  • Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS., PLoS Genetics, 11, 2015
  • Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction., Mol Neurodegener, 10, 2015
  • Development and characterization of monoclonal antibodies to detect klotho., Monoclon Antib Immunodiagn Immunother, 33, 420-7, 2014
  • MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro., Age, 36, 141-9, 2014
  • Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk., J. Biol. Chem., 2013
  • The age-regulating protein klotho is vital to sustain retinal function., Investigative Ophthalmology Visual Science, 51, 6675-85, 2013
  • Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood., Brain Res, 1527, 1-14, 2013
  • Promoter methylation and age-related downregulation of Klotho in rhesus monkey., Age, 36, 1405-19, 2012
  • Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics., Neoplasia, 2012
  • Identification of novel small molecules that elevate Klotho expression., 441, 453-61, 2012
  • Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization., Am J Neurodegener Dis, 2012
  • Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen., Molecular Therapy, 19, 1793-801, 2011
  • Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design, Clin Cancer Res, 2011
  • Gene therapy and targeted toxins for glioma., Current Gene Therapy, 44, 155-80, 2011
  • Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression., Clin Cancer Res, 2009
  • Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity., Clin Cancer Res, 2009
  • High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity., J. Virol., 82, 4680-4, 2008
  • Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits., Molecular Therapy, 16, 682-90, 2008
  • Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model., Neuro-Oncology, 10, 19-31, 2008
  • One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications., Molecular Therapy, 2007
  • Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression., J Neurooncol, 2007
  • In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain., J Exp Med, 2006
  • Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain., J Immunol, 2006
  • Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses., J Virol, 2006
  • Gene therapy and targeted toxins for glioma., Current Gene Therapy, 5, 535-57, 2005
  • Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model., Cancer Research, 65, 7194-204, 2005
  • Regulatable gene expression systems for gene therapy applications: progress and future challenges., Molecular Therapy, 2005
  • Combining cytotoxic and immune-mediated gene therapy to treat brain tumors., Curr Top Med Chem, 2005
  • Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression., Molecular Therapy, 2004
  • X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein., J Neurochem, 88, 971-82, 2004
  • Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?, Experimental Neurology, 2004
  • X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence., Neuroscience, 120, 143-54, 2003

Research and Scholarship

Research and Scholarship Interests

  • I am interested in changes that occur in the brain as a result of the normal aging process.  Understanding the breakpoints between normal aging and development of neurodegenerative disease is crucial to developing new therapies to treat and prevent neurodegeneration.

Current Research Projects


Grant Funding Received

  • Inhibitory Neural Circuits in Dentate Function - NIH/NINDS. Collaborative project with Dr. Linda Overstreet-Wadiche
  • Haddix President's Faculty Research Fund - funds to support the Creighton Brain Bee
  • CURAS Director’s Summer Undergraduate Research Fellowship - student Tavian Sanchez
  • CURAS Director’s Summer Undergraduate Research Fellowship - undergraduate Nick Sande
  • 2021 Dr. and Mrs. Randolph Ferlic Summer Undergraduate Research Fellowship - undergraduate Tavian Sanchez
  • COBRE Translational Hearing Center Pilot Grant